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Bringing Heparan Sulfate Glycomics Together with Proteomics for the Design of Novel Therapeutics: A Historical Perspective.
Published in:
Proteomics, 2019, v. 19, n. 21/22, p. N.PAG, doi. 10.1002/pmic.201800466
By:
- Nurcombe, Victor;
- Ling, Ling;
- Hondermarck, Hubert;
- Cool, Simon M.;
- Smith, Raymond A. A.
Publication type:
Article
Osteogenic Stimulation of Human Adipose‐Derived Mesenchymal Stem Cells Using a Fungal Metabolite That Suppresses the Polycomb Group Protein EZH2.
Published in:
Stem Cells Translational Medicine, 2018, v. 7, n. 2, p. 197, doi. 10.1002/sctm.17-0086
By:
- Samsonraj, Rebekah M.;
- Dudakovic, Amel;
- Manzar, Bushra;
- Sen, Buer;
- Dietz, Allan B.;
- Cool, Simon M.;
- Rubin, Janet;
- van Wijnen, Andre J.
Publication type:
Article
Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine.
Published in:
Stem Cells Translational Medicine, 2017, v. 6, n. 12, p. 2173, doi. 10.1002/sctm.17-0129
By:
- Samsonraj, Rebekah M.;
- Raghunath, Michael;
- Nurcombe, Victor;
- Hui, James H.;
- van Wijnen, Andre J.;
- Cool, Simon M.
Publication type:
Article
Microfluidic Screening Reveals Heparan Sulfate Enhances Human Mesenchymal Stem Cell Growth by Modulating Fibroblast Growth Factor-2 Transport.
Published in:
Stem Cells Translational Medicine, 2017, v. 6, n. 4, p. 1178, doi. 10.1002/sctm.16-0343
By:
- Titmarsh, Drew M.;
- Tan, Clarissa L.L.;
- Glass, Nick R.;
- Nurcombe, Victor;
- Cooper-White, Justin J.;
- Cool, Simon M.
Publication type:
Article
Regulation of embryonic stem cell fate by heparan sulfate proteoglycans.
Published in:
Cell Research, 2008, v. 18, p. S53, doi. 10.1038/cr.2008.143
By:
- Nurcombe, Victor;
- Helledie, Torben;
- Cool, Simon M.
Publication type:
Article
Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone.
Published in:
Journal of Cellular Biochemistry, 2018, v. 119, n. 7, p. 5715, doi. 10.1002/jcb.26755
By:
- Soreide, Endre;
- Denbeigh, Janet M.;
- Lewallen, Eric A.;
- Samsonraj, Rebekah M.;
- Berglund, Lawrence J.;
- Dudakovic, Amel;
- Cool, Simon M.;
- Nordsletten, Lars;
- Kakar, Sanjeev;
- van Wijnen, Andre J.
Publication type:
Article
High-Resolution Molecular Validation of Self-Renewal and Spontaneous Differentiation in Clinical-Grade Adipose-Tissue Derived Human Mesenchymal Stem Cells.
Published in:
Journal of Cellular Biochemistry, 2014, v. 115, n. 10, p. 1816, doi. 10.1002/jcb.24852
By:
- Dudakovic, Amel;
- Camilleri, Emily;
- Riester, Scott M.;
- Lewallen, Eric A.;
- Kvasha, Sergiy;
- Chen, Xiaoyue;
- Radel, Darcie J.;
- Anderson, Jarett M.;
- Nair, Asha A.;
- Evans, Jared M.;
- Krych, Aaron J.;
- Smith, Jay;
- Deyle, David R.;
- Stein, Janet L.;
- Stein, Gary S.;
- Im, Hee‐Jeong;
- Cool, Simon M.;
- Westendorf, Jennifer J.;
- Kakar, Sanjeev;
- Dietz, Allan B.
Publication type:
Article
Heparan Sulfate Proteoglycans and Human Breast Cancer Epithelial Cell Tumorigenicity.
Published in:
Journal of Cellular Biochemistry, 2014, v. 115, n. 5, p. 967, doi. 10.1002/jcb.24746
By:
- Okolicsanyi, Rachel K.;
- van Wijnen, Andre J.;
- Cool, Simon M.;
- Stein, Gary S.;
- Griffiths, Lyn R.;
- Haupt, Larisa M.
Publication type:
Article
Immobilization of vitronectin‐binding heparan sulfates onto surfaces to support human pluripotent stem cells.
Published in:
Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2018, v. 106, n. 5, p. 1887, doi. 10.1002/jbm.b.33999
By:
- Yap, Lynn;
- Murali, Sadasivam;
- Bhakta, Gajadhar;
- Titmarsh, Drew M.;
- Chen, Allen Kuan‐Liang;
- Chiin Sim, Lyn;
- Bardor, Muriel;
- Lim, Yu Ming;
- Goh, James C. H.;
- Oh, Steve K. W.;
- Choo, Andre B. H.;
- van Wijnen, Andre J.;
- Robinson, David E.;
- Whittle, Jason D.;
- Birch, William R.;
- Short, Robert D.;
- Nurcombe, Victor;
- Cool, Simon M.
Publication type:
Article
Glycosaminoglycans modulate RANKL-induced osteoclastogenesis.
Published in:
Journal of Cellular Biochemistry, 2010, v. 109, n. 6, p. 1222, doi. 10.1002/jcb.22506
By:
- Ling, Ling;
- Murali, Sadasivam;
- Stein, Gary S.;
- van Wijnen, Andre J.;
- Cool, Simon M.
Publication type:
Article
Purification and characterization of heparan sulfate from human primary osteoblasts.
Published in:
Journal of Cellular Biochemistry, 2009, v. 108, n. 5, p. 1132, doi. 10.1002/jcb.22340
By:
- Murali, Sadasivam;
- Manton, Kerry J.;
- Tjong, Vinalia;
- Su, Xiaodi;
- Haupt, Larisa M.;
- Cool, Simon M.;
- Nurcombe, Victor
Publication type:
Article
The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts.
Published in:
Journal of Cellular Biochemistry, 2009, v. 107, n. 1, p. 144, doi. 10.1002/jcb.22108
By:
- Teplyuk, Nadiya M.;
- Haupt, Larisa M.;
- Ling, Ling;
- Dombrowski, Christian;
- Mun, Foong Kin;
- Nathan, Saminathan S.;
- Lian, Jane B.;
- Stein, Janet L.;
- Stein, Gary S.;
- Cool, Simon M.;
- van Wijnen, Andre J.
Publication type:
Article
Regulated expression of syndecan-4 in rat calvaria osteoblasts induced by fibroblast growth factor-2.
Published in:
Journal of Cellular Biochemistry, 2007, v. 100, n. 2, p. 402, doi. 10.1002/jcb.21068
By:
- Song, Shu Jun;
- Cool, Simon M.;
- Nurcombe, Victor
Publication type:
Article
Heparan sulfate regulation of progenitor cell fate.
Published in:
Journal of Cellular Biochemistry, 2006, v. 99, n. 4, p. 1040, doi. 10.1002/jcb.20936
By:
- Simon M. Cool;
- Victor Nurcombe
Publication type:
Article
Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling.
Published in:
Glycobiology, 2015, v. 25, n. 12, p. 1491, doi. 10.1093/glycob/cwv064
By:
- Lee, Jonathan;
- Sheena Wee;
- Gunaratne, Jayantha;
- Chua, R. J. E.;
- Smith, Raymond A. A.;
- Ling Ling;
- Fernig, David G.;
- Swaminathan, Kunchithapadam;
- Nurcombe, Victor;
- Cool, Simon M.
Publication type:
Article
Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
Published in:
Arthritis Research & Therapy, 2011, v. 13, n. 4, p. 1, doi. 10.1186/ar3441
By:
- Dongyao Yan;
- Di Chen;
- Cool, Simon M.;
- Van Wijnen, Andre J.;
- Mikecz, Katalin;
- Murphy, Gillian;
- Hee-Jeong Im
Publication type:
Article
Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
Published in:
Arthritis Research & Therapy, 2024, v. 26, n. 1, p. 1, doi. 10.1186/s13075-024-03381-y
By:
- Yan, Dongyao;
- Chen, Di;
- Cool, Simon M;
- van Wijnen, Andre J;
- Mikecz, Katalin;
- Murphy, Gillian;
- Im, Hee-Jeong
Publication type:
Article
Temporal expression of fibroblast growth factor receptors during primary ligament repair.
Published in:
2004
By:
- Cool, Simon M.;
- Snyman, Charles P.;
- Nurcombe, Victor;
- Forwood, Mark
Publication type:
journal article
Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-38818-y
By:
- Luo, Xiaoman;
- Lau, Chau Sang;
- Le, Bach Quang;
- Tan, Tuan Chun;
- Too, Jian Hui;
- Smith, Raymond Alexander Alfred;
- Yu, Na;
- Cool, Simon M.
Publication type:
Article
Complexation and Sequestration of BMP-2 from an ECM Mimetic Hyaluronan Gel for Improved Bone Formation.
Published in:
PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0078551
By:
- Kisiel, Marta;
- Klar, Agnieszka S.;
- Ventura, Manuela;
- Buijs, Jos;
- Mafina, Marc-Krystelle;
- Cool, Simon M.;
- Hilborn, Jöns
Publication type:
Article
The use of heparan sulfate to augment fracture repair in a rat fracture model.
Published in:
Journal of Orthopaedic Research, 2006, v. 24, n. 4, p. 636, doi. 10.1002/jor.20103
By:
- Jackson, Rebecca A.;
- McDonald, Michelle M.;
- Nurcombe, Victor;
- Little, David G.;
- Cool, Simon M.
Publication type:
Article
Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces.
Published in:
Stem Cells International, 2015, v. 2015, p. 1, doi. 10.1155/2015/752424
By:
- Hartrianti, Pietradewi;
- Ling, Ling;
- Goh, Lyn Mei Ming;
- Ow, Kok Seng Amos;
- Samsonraj, Rebekah Margaret;
- Sow, Wan Ting;
- Wang, Shuai;
- Nurcombe, Victor;
- Cool, Simon M.;
- Ng, Kee Woei
Publication type:
Article
Functional maturation of isolated neural progenitor cells from the adult rat hippocampus.
Published in:
European Journal of Neuroscience, 2004, v. 19, n. 9, p. 2410, doi. 10.1111/j.0953-816X.2004.03346.x
By:
- Hogg, Ron C.;
- Chipperfield, Hiram;
- Whyte, Kathryn A.;
- Stafford, Mark R.;
- Hansen, Mitchell A.;
- Cool, Simon M.;
- Nurcombe, Victor;
- Adams, David J.
Publication type:
Article
Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo.
Published in:
2009
By:
- Tonks, Ian D.;
- Mould, Arne;
- Nurcombe, Victor;
- Cool, Simon M.;
- Walker, Graeme J.;
- Hacker, Elke;
- Keith, Patricia;
- Schroder, Wayne A.;
- Cotterill, Andrew;
- Hayward, Nicholas K.;
- Kay, Graham F.
Publication type:
Letter
In Reply.
Published in:
2020
By:
- Cool, Simon M.;
- Sathiyanathan, Padmapriya;
- Samsonraj, Rebekah M.;
- Tan, Clarissa L. L.;
- Ling, Ling;
- Lezhava, Alexander;
- Nurcombe, Victor;
- Stanton, Lawrence W.
Publication type:
Letter to the Editor
A genomic biomarker that identifies human bone marrow‐derived mesenchymal stem cells with high scalability.
Published in:
Stem Cells, 2020, v. 38, n. 9, p. 1124, doi. 10.1002/stem.3203
By:
- Sathiyanathan, Padmapriya;
- Samsonraj, Rebekah M.;
- Tan, Clarissa L. L.;
- Ling, Ling;
- Lezhava, Alexander;
- Nurcombe, Victor;
- Stanton, Lawrence W.;
- Cool, Simon M.
Publication type:
Article
Establishing Criteria for Human Mesenchymal Stem Cell Potency.
Published in:
Stem Cells, 2015, v. 33, n. 6, p. 1878, doi. 10.1002/stem.1982
By:
- Samsonraj, Rebekah M.;
- Nurcombe, Victor;
- Rai, Bina;
- Cool, Simon M.;
- Sathiyanathan, Padmapriya;
- Stanton, Lawrence W.;
- Puan, Kia Joo;
- Rötzschke, Olaf;
- Hui, James H.;
- Raghunath, Michael
Publication type:
Article
FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin-Dependent Kinase Inhibitors p21<sup>Waf1</sup> and p27<sup>Kip1</sup>.
Published in:
Stem Cells, 2013, v. 31, n. 12, p. 2724, doi. 10.1002/stem.1514
By:
- Dombrowski, Christian;
- Helledie, Torben;
- Ling, Ling;
- Grünert, Martin;
- Canning, Claire A.;
- Jones, C. Michael;
- Hui, James H.;
- Nurcombe, Victor;
- van Wijnen, Andre J.;
- Cool, Simon M.
Publication type:
Article
Autocrine Fibroblast Growth Factor 2 Increases the Multipotentiality of Human Adipose-Derived Mesenchymal Stem Cells.
Published in:
Stem Cells, 2008, v. 26, n. 6, p. 1598, doi. 10.1634/stemcells.2007-0480
By:
- Rider, David A.;
- Dombrowski, Christian;
- Sawyer, Amber A.;
- Ng, Grace H. B.;
- Leong, David;
- Hutmacher, Dietmar W.;
- Nurcombe, Victor;
- Cool, Simon M.
Publication type:
Article
Disruption of Heparan and Chondroitin Sulfate Signaling Enhances Mesenchymal Stem Cell-Derived Osteogenic Differentiation via Bone Morphogenetic Protein Signaling Pathways.
Published in:
Stem Cells, 2007, v. 25, n. 11, p. 2845, doi. 10.1634/stemcells.2007-0065
By:
- Manton, Kerry J.;
- Leong, Denise F. M.;
- Cool, Simon M.;
- Nurcombe, Victor
Publication type:
Article
Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy.
Published in:
Molecular Cancer, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12943-015-0391-4
By:
- Ling Ling;
- Si Kee Tan;
- Ting Hwee Goh;
- Cheung, Edwin;
- Nurcombe, Victor;
- van Wijnen, Andre J.;
- Cool, Simon M.
Publication type:
Article
Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy.
Published in:
Molecular Cancer, 2015, v. 14, n. 1, p. 136, doi. 10.1186/s12943-015-0391-4
By:
- Ling, Ling;
- Tan, Si Kee;
- Goh, Ting Hwee;
- Cheung, Edwin;
- Nurcombe, Victor;
- van Wijnen, Andre J.;
- Cool, Simon M.
Publication type:
Article
Affinity Selection of FGF2-Binding Heparan Sulfates for Ex Vivo Expansion of Human Mesenchymal Stem Cells.
Published in:
Journal of Cellular Physiology, 2017, v. 232, n. 3, p. 566, doi. 10.1002/jcp.25454
By:
- Wijesinghe, Sampath Jeewantha;
- Ling, Ling;
- Murali, Sadasivam;
- Qing, Yeong Hui;
- Hinkley, Simon F.R.;
- Carnachan, Susan M.;
- Bell, Tracey J.;
- Swaminathan, Kunchithapadam;
- Hui, James H.;
- van Wijnen, Andre J.;
- Nurcombe, Victor;
- Cool, Simon M.
Publication type:
Article
FGF-2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3-K/GSK3β signaling.
Published in:
Journal of Cellular Physiology, 2010, v. 225, n. 2, p. 417, doi. 10.1002/jcp.22214
By:
- DING, VANESSA M. Y.;
- LING LING;
- NATARAJAN, SUBAASHINI;
- YAP, MIRANDA G. S.;
- COOL, SIMON M.;
- CHOO, ANDRE B. H.
Publication type:
Article
Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).
Published in:
Journal of Cellular Physiology, 2009, v. 221, n. 3, p. 778, doi. 10.1002/jcp.21921
By:
- PEREIRA, BARRY P.;
- ZHOU, YEFANG;
- GUPTA, ANURAG;
- LEONG, DAVID T.;
- AUNG, KHIN ZARCHI;
- LING, LING;
- PHO, ROBERT W. H.;
- GALINDO, MARIO;
- SALTO-TELLEZ, MANUEL;
- STEIN, GARY S.;
- COOL, SIMON M.;
- VAN WIJNEN, ANDRE J.;
- NATHAN, SAMINATHAN S.
Publication type:
Article
The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis.
Published in:
Journal of Cellular Physiology, 2009, v. 220, n. 3, p. 780, doi. 10.1002/jcp.21825
By:
- HAUPT, LARISA M.;
- MURALI, SADASIVAM;
- FOONG KIN MUN;
- TEPLYUK, NADIYA;
- LEONG FONG MEI;
- STEIN, GARY S.;
- WIJNEN, ANDRE J. VAN;
- NURCOMBE, VICTOR;
- COOL, SIMON M.
Publication type:
Article
Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2.
Published in:
Journal of Cellular Physiology, 2007, v. 210, n. 1, p. 38, doi. 10.1002/jcp.20813
By:
- Jackson, Rebecca A.;
- Murali, Sadasivam;
- van Wijnen, Andre J.;
- Stein, Gary S.;
- Nurcombe, Victor;
- Cool, Simon M.
Publication type:
Article
Sulfated glycosaminoglycans mediate the effects of FGF2 on the osteogenic potential of rat calvarial osteoprogenitor cells.
Published in:
Journal of Cellular Physiology, 2006, v. 209, n. 3, p. 811, doi. 10.1002/jcp.20760
By:
- Ling Ling;
- Murali, Sadasivam;
- Dombrowski, Christian;
- Haupt, Larisa M.;
- Stein, Gary S.;
- Van Wijnen, Andre J.;
- Nurcombe, Victor;
- Cool, Simon M.
Publication type:
Article
Long-term loading inhibits ERK1/2 phosphorylation and increases FGFR3 expression in MC3T3-E1 osteoblast cells.
Published in:
Journal of Cellular Physiology, 2006, v. 209, n. 3, p. 894, doi. 10.1002/jcp.20779
By:
- Jackson, Rebecca A.;
- Kumarasuriyar, Arjuna;
- Nurcombe, Victor;
- Cool, Simon M.
Publication type:
Article
Bone-specific heparan sulfates induce osteoblast growth arrest and downregulation of retinoblastoma protein.
Published in:
Journal of Cellular Physiology, 2006, v. 209, n. 1, p. 219, doi. 10.1002/jcp.20727
By:
- Manton, Kerry J.;
- Sadasivam, Murali;
- Cool, Simon M.;
- Nurcombe, Victor
Publication type:
Article
The development of heparan sulfate sugars as therapeutics: Versatility that couples stem cells, tissue engineering, and wound repair.
Published in:
Drug Development Research, 2004, v. 62, n. 4, p. 303, doi. 10.1002/ddr.10395
By:
- Victor Nurcombe;
- Arjuna Kumarasuriyar;
- Simon M. Cool
Publication type:
Article
New strategies for cartilage regeneration exploiting selected glycosaminoglycans to enhance cell fate determination.
Published in:
Biochemical Society Transactions, 2014, v. 42, n. 3, p. 703, doi. 10.1042/BST20140031
By:
- Ayerst, Bethanie I.;
- Day, Anthony J.;
- Nurcombe, Victor;
- Cool, Simon M.;
- Merry, Catherine L. R.
Publication type:
Article
Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion.
Published in:
PLoS ONE, 2015, v. 10, n. 9, p. 1, doi. 10.1371/journal.pone.0137255
By:
- Okolicsanyi, Rachel K.;
- Camilleri, Emily T.;
- Oikari, Lotta E;
- Yu, Chieh;
- Cool, Simon M.;
- van Wijnen, Andre J.;
- Griffiths, Lyn R.;
- Haupt, Larisa M.
Publication type:
Article

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