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- Title
Long-Term Survival and Factors Associated with Increased Mortality in Patients with Ocular Adnexal Lymphomas.
- Authors
Strianese, Diego; Laezza, Maria Paola; Tortora, Fabio; Fusco, Giancarlo; de Divitiis, Oreste; D'Aponte, Antonella; Briganti, Francesco; Elefante, Andrea
- Abstract
Simple Summary: Orbital and ocular adnexal lymphoma (OAL) refers to a type of cancer affecting the eye and its surrounding structures. It typically originates from lymphoid tissue and can manifest with different variants, including the non-Hodgkin subtype. While prognosis is generally favorable, this relies on different factors, including early detection, prompt treatment, and cancer subtype. This observational study on diagnostic and prognostic factors in OAL aims to provide significant information about the relationship between imaging and disease outcomes. We conclude that by analyzing radiological features such as subtype, fluorodeoxyglucose avidity, and bone marrow involvement, researchers can identify potential prognostic indicators, ultimately helping clinicians in predicting disease progression, refining diagnostic protocols, and improving patient outcomes. Orbital and ocular adnexal lymphoma (OAL) affects the orbit and the surrounding structures and can arise as several subtypes with variable prognoses. We performed an observational study on the relationship between OAL subtype, diagnostic features, and prognosis to offer valuable insights into imaging techniques, such as Positron Emission Tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with Computed Tomography (18F-FDG PET-CT), in predicting outcomes. With this aim, we retrospectively reviewed 99 patients with OALs, recording demographics, cancer subtype, location and treatment, 18FDG avidity, and bone marrow positivity. We divided patients into Group 1 (those presenting with extranodal marginal zone lymphoma—EMZL) and Group 2, including all other subtypes. The primary outcome was long-term cancer-specific survival (CSS) based on key predictors, performed through Kaplan–Meier curves and the log-rank test, with a p < 0.05 significance threshold. The mean patient age was 67 years (57–75.5). The most frequent histopathologic subtypes were EMZL lymphoma in 69 patients (69.7%), small lymphocytic lymphoma (11.1%) and diffuse-large B-cell lymphoma (10.1%). Patients of Group 1 showed a better prognosis (CSS = 80%) compared to those of Group 2 (CSS = 60%) (p = 0.01). In patients with high-grade lymphoma, the occurrence of 18FDG avidity (p = 0.003) and bone marrow positivity (p = 0.005) were related to a worse prognosis. In our group, EMZL was the most prominent subtype of OALs and exhibited the best prognosis, low 18FDG avidity, and bone marrow negativity. By observing specific patterns in radiological findings, it is possible to increase our understanding of disease progression, treatment response, and the overall prognosis in OAL patients.
- Subjects
RADIOPHARMACEUTICALS; BONE marrow; OCULAR tumors; DEOXY sugars; COMPUTED tomography; CAUSES of death; POSITRON emission tomography; RETROSPECTIVE studies; DESCRIPTIVE statistics; KAPLAN-Meier estimator; MEDICAL records; ACQUISITION of data; B cell lymphoma
- Publication
Cancers, 2024, Vol 16, Issue 12, p2252
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16122252