We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tolerance of Infants Fed a Hydrolyzed Rice Infant Formula with 2′-Fucosyllactose (2′-FL) Human Milk Oligosaccharide (HMO).
- Authors
Ramirez-Farias, Carlett; Oliver, Jeffery S.; Schlezinger, Jane; Stutts, John T.
- Abstract
Background: The purpose of this research was to assess the growth, tolerance, and compliance outcomes associated with the consumption of a hydrolyzed rice infant formula (HRF) enriched with 2′-Fucosyllactose (2′-FL) a Human Milk Oligosaccharide (HMO), and nucleotides in an intended population of infants. Methods: This was a non-randomized single-group, multicenter study. The study formula was a hypoallergenic HRF with 2′-FL, Docosahexaenoic acid (DHA), Arachidonic acid (ARA), and nucleotides. Infants 0–90 days of age who were formula fed and experiencing persistent feeding intolerance symptoms, symptoms of suspected food protein (milk and/or soy) allergy, or other conditions where an extensively hydrolyzed infant formula was deemed an appropriate feeding option were recruited by pediatricians from their local populations. The primary outcome was maintenance of weight-for-age z-score. Weight, length, head circumference, formula intake, tolerance measures, clinical symptoms and questionnaires were collected. Thirty-three infants were enrolled, and 27 completed the study, on study product. Results: Weight-for-age z-scores of infants showed a statistically significant improvement from Visit 1 to Visit 4 (p = 0.0331). There was an adequate daily volume intake of 762 ± 28 mL/day, average daily number of stools of 2.1 ± 0.3, and mean rank stool consistency of 2.38 ± 0.18. After 28 days of switching to a HRF, 86.8 ± 5.9% of the symptoms resolved or got better by Visit 4 as reported by parents. Conclusions: HRF with 2′-FL HMO was safe, well tolerated, and supported weight gain in infants with suspected cow's milk allergy or persistent feeding intolerance.
- Subjects
PATIENT compliance; DOCOSAHEXAENOIC acid; INFANTS; INFANT development; FOOD consumption; ARACHIDONIC acid; RESEARCH funding; RICE; FOOD safety; CLINICAL trials; FOOD allergy; HUMAN growth; BREAST milk; TREATMENT effectiveness; DESCRIPTIVE statistics; INFANT physiology; NUTRITIONAL requirements; INFANT formulas; INFANT nutrition; NUCLEOTIDES; EXPERIMENTAL design; MILK proteins; FOOD intolerance; BABY foods; RESEARCH; ANTHROPOMETRY; OLIGOSACCHARIDES; WEIGHT gain; CHILDREN
- Publication
Nutrients, 2024, Vol 16, Issue 12, p1863
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16121863