We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association Between Genes in the Nuclear Factor E2-Related Factor 2 Antioxidative Response Elements Pathway and CancerRelated Fatigue in Women With Early-Stage Breast Cancer.
- Authors
Davis, Tara S.; Koleck, Theresa A.; Rosenzweig, Margaret Q.; Miaskowski, Christine; Erickson, Kirk I.; Sereika, Susan M.; Bender, Catherine M.; Conley, Yvette P.
- Abstract
OBJECTIVES: To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2- ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer. SAMPLE & SETTING: Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania. METHODS & VARIABLES: Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity. RESULTS: The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity. IMPLICATIONS FOR NURSING: Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.
- Subjects
PENNSYLVANIA; BREAST tumor diagnosis; CROSS-sectional method; PEARSON correlation (Statistics); RESEARCH funding; BREAST tumors; FATIGUE (Physiology); LOGISTIC regression analysis; SCIENTIFIC observation; FISHER exact test; CELLULAR signal transduction; POSTMENOPAUSE; CHI-squared test; DESCRIPTIVE statistics; SEVERITY of illness index; OXIDATIVE stress; BRIEF Pain Inventory; GENE expression; DISEASES; DNA methylation; ANTIOXIDANTS; RESEARCH; STATISTICS; TUMOR classification; DATA analysis software; CONFIDENCE intervals; PSYCHOLOGICAL tests; NUCLEAR factor E2 related factor; REGRESSION analysis; GENOTYPES; CLASSIFICATION; DISEASE complications
- Publication
Oncology Nursing Forum, 2024, Vol 51, Issue 4, p404
- ISSN
0190-535X
- Publication type
Article
- DOI
10.1188/24.ONF.404-416