We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The soluble guanylyl cyclase activator BAY 60-2770 potently relaxes the pulmonary artery on congenital diaphragmatic hernia rabbit model.
- Authors
Rojas-Moscoso, Julio; Antunes, Edson; Figueira, Rebeca; Gonçalves, Frances; Simões, Ana; Sbragia, Lourenço
- Abstract
Purpose: Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypertension which is often difficult to manage, and a significant cause of morbidity and mortality. In this study, we have used a rabbit model of CDH to evaluate the effects of BAY 60-2770 on the in vitro reactivity of left pulmonary artery. Methods: CDH was performed in New Zealand rabbit fetuses ( n = 10 per group) and compared to controls. Measurements of body, total and left lung weights (BW, TLW, LLW) were done. Pulmonary artery rings were pre-contracted with phenylephrine (10 μM), after which cumulative concentration-response curves to glyceryl trinitrate (GTN; NO donor), tadalafil (PDE5 inhibitor) and BAY 60-2770 (sGC activator) were obtained as well as the levels of NO (NO/NO). Results: LLW, TLW and LBR were decreased in CDH ( p < 0.05). In left pulmonary artery, the potency (pEC) for GTN was markedly lower in CDH (8.25 ± 0.02 versus 9.27 ± 0.03; p < 0.01). In contrast, the potency for BAY 60-2770 was markedly greater in CDH (11.7 ± 0.03 versus 10.5 ± 0.06; p < 0.01). The NO/NO levels were 62 % higher in CDH ( p < 0.05). Conclusion: BAY 60-2770 exhibits a greater potency to relax the pulmonary artery in CDH, indicating a potential use for pulmonary hypertension in this disease.
- Subjects
GUANYLATE cyclase; PULMONARY artery diseases; HUMAN abnormalities; DIAPHRAGMATIC hernia; LABORATORY rabbits; PULMONARY hypertension; MORTALITY
- Publication
Pediatric Surgery International, 2014, Vol 30, Issue 10, p1031
- ISSN
0179-0358
- Publication type
Article
- DOI
10.1007/s00383-014-3561-3