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- Title
Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis.
- Authors
Cho, Se Jin; Lee, Jeong Hyun; Suh, Chong Hyun; Kim, Jung Youn; Kim, Donghyun; Lee, Jung Bin; Lee, Min Kyoung; Chung, Sae Rom; Choi, Young Jun; Baek, Jung Hwan
- Abstract
<bold>Objective: </bold>To compare the diagnostic performance of contrast-enhanced CT with that of MRI in the detection of cartilage invasion in patients with laryngo-hypopharyngeal cancer.<bold>Methods: </bold>A systematic literature search in the Ovid-MEDLINE and EMBASE databases was performed for studies reporting diagnostic accuracy of CT and/or MRI in detecting cartilage invasion from laryngo-hypopharyngeal cancer between 2000 and 2018. The pooled sensitivity and specificity, and their 95% confidence intervals were calculated for CT and MRI using bivariate random effects modeling. Subgroup and meta-regression analyses were performed. Indirect comparison was also performed by univariable meta-regression.<bold>Result: </bold>Fourteen articles including 776 patients were included in the systematic review and meta-analysis: eight for CT, and six for MRI. CT and MRI showed pooled sensitivities of 66% (95% CI, 49-80%) and 88% (95% CI, 79-93%), and pooled specificities of 90% (95% CI, 82-94%) and 81% (95% CI, 76-84%), respectively. MRI showed significantly higher sensitivity than CT (p = 0.02). The specificities showed no statistically significant difference between CT and MRI (p = 0.39). The CT studies showed heterogeneity and a threshold effect, while MRI showed neither heterogeneity nor threshold effect. In the meta-regression analysis for CT, the type of cartilage analyzed (thyroid only vs. thyroid/cricoid/arytenoid, p < 0.001) was a significant factor influencing the heterogeneity in the diagnostic performance of the CT studies.<bold>Conclusions: </bold>In conclusion, MRI has significantly higher sensitivity than CT for detecting cartilage invasion in patients with laryngo-hypopharyngeal cancer, without a significant difference in the specificity.<bold>Key Points: </bold>• MRI has significantly higher sensitivity than CT for detecting cartilage invasion in patients with laryngo-hypopharyngeal cancer.
- Subjects
TUMOR classification; CARTILAGE; META-analysis; RANDOM effects model; CANCER patients; CHONDROSARCOMA; RESEARCH; CANCER invasiveness; RESEARCH methodology; SYSTEMATIC reviews; MAGNETIC resonance imaging; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; COMPUTED tomography; HYPOPHARYNGEAL cancer
- Publication
European Radiology, 2020, Vol 30, Issue 7, p3803
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-020-06718-8