We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Correlation between (18)F-FDG uptake on PET/CT and prognostic factors in triple-negative breast cancer.
- Authors
Koo, Hye; Park, Jeong; Kang, Keon; Han, Wonshik; Park, In; Moon, Woo; Koo, Hye Ryoung; Park, Jeong Seon; Kang, Keon Wook; Park, In Ae; Moon, Woo Kyung
- Abstract
<bold>Objectives: </bold>The purpose of this study was to investigate whether a correlation exists between (18)F-fluorodeoxyglucose (FDG) uptake and prognostic factors in triple-negative breast cancer (TNBC).<bold>Methods: </bold>Between January 2009 and December 2013, 103 patients (mean age, 50.6 years) with primary TNBC (mean, 2.6 cm; range, 1.0-6.5 cm) underwent (18)F-FDG PET/CT for initial staging. Correlations between maximum standardized uptake value (SUVmax) on PET/CT and prognostic factors including tumour size, nodal status, histological grade, Ki-67 proliferation index, tumour suppressor p53, and 'basal-like' markers (epidermal growth factor receptor and CK 5/6) were assessed.<bold>Results: </bold>The mean SUVmax of the 103 tumours was 10.94 ± 5.25 (range: 2-32.8). There was a positive correlation between SUVmax and Ki-67 (Spearman's rho = 0.29, P = 0.003) and tumour size (Spearman's rho = 0.27, P = 0.006), whereas this relationship was not observed in the nodal status, histological grade, p53 status and 'basal-like' phenotypes. In a multivariate regression analysis, Ki-67 (P < 0.001) and tumour size (P = 0.009) were significantly associated with SUVmax in TNBCs.<bold>Conclusions: </bold>Increased (18)F-FDG uptake on PET/CT was correlated with a high Ki-67 proliferation index and larger tumour size in TNBC. These results suggest a potential role of (18)F-FDG PET/CT in identifying TNBC with more aggressive behaviour.<bold>Key Points: </bold>• A wide range of FDG uptake reflected heterogeneity of cancer metabolism. • FDG uptake was correlated with the Ki-67 proliferation index in TNBC. • FDG uptake was correlated with tumour size in TNBC. • FDG uptake was not correlated with 'basal-like' phenotype.
- Subjects
FLUORODEOXYGLUCOSE F18; BREAST cancer prognosis; BREAST cancer patients; POSITRON emission tomography; COMPUTED tomography; STATISTICAL correlation; BREAST cancer diagnosis; BREAST tumor diagnosis; DUCTAL carcinoma; ANTHROPOMETRY; DEOXY sugars; PROGNOSIS; RADIOPHARMACEUTICALS; TUMOR markers; DIAGNOSIS
- Publication
European Radiology, 2015, Vol 25, Issue 11, p3314
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-3734-z