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- Title
Challenges for molecular and serological ZIKV infection confirmation.
- Authors
de Vasconcelos, Zilton Farias Meira; Azevedo, Renata Campos; Thompson, Nathália; Gomes, Leonardo; Guida, Letícia; Moreira, Maria Elisabeth Lopes
- Abstract
Background: Zika Virus (ZIKV), member of Flaviviridae family and Flavivirus genus, has recently emerged as international public health emergency after its association with neonatal microcephaly cases. Clinical diagnosis hindrance involves symptom similarities produced by other arbovirus infections, therefore laboratory confirmation is of paramount importance. Discussion: The most reliable test available is based on ZIKV RNA detection from body fluid samples. However, short viremia window periods and asymptomatic infections diminish the success rate for RT-PCR positivity. Beyond molecular detection, all serology tests in areas where other Flavivirus circulates proved to be a difficult task due to the broad range of cross-reactivity, especially with dengue pre-exposed individuals. Conclusion: Altogether, lack of serological diagnostic tools brings limitations to any retrospective evaluation. Those studies are central in the context of congenital infection that could occur asymptomatically and mask prevalence and risk rates.
- Subjects
ZIKA virus infections; MOLECULAR diagnosis; MICROCEPHALY; ARBOVIRUS diseases; VIREMIA; DIAGNOSIS
- Publication
Child's Nervous System, 2018, Vol 34, Issue 1, p79
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-017-3641-5