We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Propranolol and oxytocin versus oxytocin alone for induction and augmentation of labor: a meta-analysis of randomized trials.
- Authors
Pergialiotis, Vasilios; Frountzas, Maximos; Prodromidou, Anastasia; Prapa, Sofia; Perrea, Despina; Vlachos, Georgios; Perrea, Despina N; Vlachos, Georgios D
- Abstract
<bold>Background: </bold>We sought to study the effect of propranolol co-administration with oxytocin during the latent and active phases of labor on labor outcomes.<bold>Materials and Methods: </bold>We searched Medline, Scopus, ClinicalTrials.gov and Cochrane Central Register databases. The meta-analysis was performed with the RevMan 5.1 software. Six studies were included in the present meta-analysis which enrolled 609 parturient.<bold>Results: </bold>According to the findings of our study, propranolol administration during the latent phase effectively reduces the cesarean section rates (OR 0.49, 95 % CI 0.27, 0.89). However, this beneficial effect is not observed during the active phase of labor. The 5 min neonatal Apgar scores are not influenced by its administration (MD -0.07, 95 % CI -0.017, 0.02). Respectively, the neonatal admissions to a NICU are similar to those of neonates exposed only to oxytocin (OR 0.96, 95 % CI 0.36, 2.53).<bold>Conclusion: </bold>Propranolol's effect on the duration of the various stages of labor was underreported, however, evidence seem to support that it shortens the latent phase and possibly the total duration of labor. Firm results are, however, precluded due to the low number enrolled parturient and due to the significant methodological heterogeneity of included studies.
- Subjects
INDUCED labor (Obstetrics); PROPRANOLOL; OXYTOCIN; DRUG administration; DRUG efficacy; RANDOMIZED controlled trials; META-analysis; THERAPEUTICS; CESAREAN section; LABOR (Obstetrics); LABOR complications (Obstetrics); TREATMENT effectiveness; OXYTOCICS
- Publication
Archives of Gynecology & Obstetrics, 2016, Vol 293, Issue 4, p721
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-015-3991-8