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- Title
GLP1-GIP receptor co-agonists: a promising evolution in the treatment of type 2 diabetes.
- Authors
Ciardullo, Stefano; Morieri, Mario Luca; Daniele, Giuseppe; Fiorentino, Teresa Vanessa; Mezza, Teresa; Tricò, Domenico; Consoli, Agostino; Del Prato, Stefano; Giorgino, Francesco; Piro, Salvatore; Solini, Anna; Avogaro, Angelo
- Abstract
Type 2 diabetes represents a growing challenge for global public health. Its prevalence is increasing worldwide, and, like obesity, it affects progressively younger populations compared to the past, with potentially greater impact on chronic complications. Dual glucagon like peptide 1 (GLP1) and glucose-dependent insulinotropic peptide (GIP) receptor agonists are among the new pharmacological strategies recently developed to address this challenge. Tirzepatide, characterized by its ability to selectively bind and activate receptors for the intestinal hormones GIP and GLP-1, has been tested in numerous clinical studies and is already currently authorized in several countries for the treatment of type 2 diabetes and obesity. In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials.
- Subjects
TYPE 2 diabetes; GASTRIC inhibitory polypeptide; LITERATURE reviews; HORMONE receptors; GLUCAGON-like peptide 1
- Publication
Acta Diabetologica, 2024, Vol 61, Issue 8, p941
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-024-02300-6