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- Title
Complete nucleotide sequence analysis of a Dengue-1 virus isolated on Easter Island, Chile.
- Authors
Cáceres, C.; Yung, V.; Araya, P.; Tognarelli, J.; Villagra, E.; Vera, L.; Fernández, J.
- Abstract
Dengue-1 viruses responsible for the dengue fever outbreak in Easter Island in 2002 were isolated from acute-phase sera of dengue fever patients. In order to analyze the complete genome sequence, we designed primers to amplify contiguous segments across the entire sequence of the viral genome. RT-PCR products obtained were cloned, and complete nucleotide and deduced amino acid sequences were determined. This report constitutes the first complete genetic characterization of a DENV-1 isolate from Chile. Phylogenetic analysis shows that an Easter Island isolate is most closely related to Pacific DENV-1 genotype IV viruses.
- Subjects
EASTER Island; CHILE; DENGUE; AMINO acids; AMINO acid sequence; GENETICS; GENETIC polymorphisms
- Publication
Archives of Virology, 2008, Vol 153, Issue 10, p1967
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-008-0200-0