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- Title
Do severe systemic sequelae of proteinuria modulate the antiproteinuric response to chronic ACE inhibition?
- Authors
Bos, Hendrik; Henning, Robert H.; de Jong, Paul E.; de Zeeuw, Dick; Navis, Gerjan
- Abstract
Background. ACE inhibition exerts an antiproteinuric and renoprotective effect. However, residual proteinuria is often present. As residual proteinuria is associated with a poor renal outcome, identification of its determinants is important. We found previously that the systemic sequelae of proteinuria enhance renal damage in untreated nephrotic rats. The impact of systemic nephrosis on renal therapy response, however, is unclear. In the present study we therefore investigated whether the severity of systemic nephrosis, estimated from plasma cholesterol, predicts residual proteinuria during ACE inhibition.
- Publication
Nephrology Dialysis Transplantation, 2002, Vol 17, Issue 5, p793
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/17.5.793