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- Title
Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia‐reperfusion injury.
- Authors
Lui, Sing Leung; Chan, Loretta Yuk Yee; Zhang, Xiao Hui; Zhu, Wen; Chan, Tak Mao; Fung, Peter Chin Wan; Lai, Kar Neng
- Abstract
Background. Recent animal data suggest that inducible nitric oxide synthase (iNOS) derived nitric oxide (NO) plays an important role in the pathogenesis of renal ischaemia‐reperfusion injury (IRI) and that inhibition of iNOS ameliorates IRI. Mycophenolate mofetil (MMF), a lymphocyte selective anti‐proliferative agent, has been shown to inhibit NO production in vitro. The aim of this study is to evaluate the effect of MMF on NO production and iNOS gene expression in vivo during renal IRI.
- Publication
Nephrology Dialysis Transplantation, 2001, Vol 16, Issue 8, p1577
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/16.8.1577