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- Title
Synergic activity of imipenem/cilastatin combined with cefotiam against methicillin-resistant Staphylococcus aureus.
- Authors
Oka, Shinichi; Goto, Mieko; Kaji, Yoshiko; Kimura, Satoshi; Matsuda, Kouji; Asahi, Yoshinari; Sanada, Minoru; Nakagawah, Susumu; Inoue, Matsuhisa; Shlmada, Kaoru; Oka, S; Goto, M; Kaji, Y; Kimura, S; Matsuda, K; Asahi, Y; Sanada, M; Nakagawa, S; Inoue, M; Shimada, K
- Abstract
The synergic activity of imipenem/cilastatin combined with cefotiam was studied in a mouse bacteraemia mod.el. Combinations of imipenem plus cefotiam in ratios from 1: 5 to I : 160 were more effective than either imipenem alone or cefotiam alone (P < 0·05). Synergy was observed against both β-lactamase producing and β-lactamase non-producing MRSA. Staggered combinations of imipenem with cefotiam (each drug was administered at a different time) were studied in an in-vitro pharmacokinetic system to clarify relationships between killing kinetics and pharmacodynamics of the combinations. In the in-vitro system, cefotiam (1 g over 30 mm) administered 2 h after imipenem administration (250 mg over 30 mm) reduced viable cell counts to an undetectable level and maintained this for 4 h, while the simultaneous administration of imipenem and cefotiam maintained an undetectable cell count for only 2 h. Furthermore, imipenem administered after cefotiam showed no synergy. These results indicate that the timing of dosing of each antibiotic influences synergy, and administration of cefotiam 2 h after imipenemis more effective than the other regimens.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 31, Issue 4, p533
- ISSN
0305-7453
- Publication type
journal article