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- Title
Comparative in-vitro activity of five fluoroquinolones against mycobacteria.
- Authors
Davies, S.; Sparham, P. D.; Spencer, R. C.
- Abstract
Fifty distinct strains of mycobacteria were investigated to determine their in-vitro susceptibility to five new fluoroquinolones (norfloxacin, pefloxacin, ofloxacin, enoxacin and ciprofloxacin). Ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentrations (MIC) of 1.25 mg/l or less to all strains of Mycobacterium tuberculosis, M. bovis, M. xenopi, M. kansasii and BCG tested. All agents showed little activity against M. malmoense and M. avium-intracellulare complex with MIC values of greater than 2.5 mg/l.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 19, Issue 5, p605
- ISSN
0305-7453
- Publication type
journal article