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- Title
Comparative efficacy and safety of ceftizoxime, cefotaxime and latamoxef in the treatment of bacterial pneumonia in high risk patients.
- Authors
Yangco, Bienvenido G.; Baird, Ian; Lorber, Bennett; Noble, Robert; Bermudez, Ramon; Silverblatt, Fred; Vasquez, Guillermo; Yangco, B G; Baird, I; Lorber, B; Noble, R; Bermudez, R; Silverblatt, F; Vasquez, G
- Abstract
One hundred and thirty-five patients with bacterial pneumonia who had risk factors (alcoholism, chronic obstructive pulmonary disease, corticosteroid therapy diabetes mellitus, advanced age, solid tumours) were randomly allocated in a double-blind fashion to receive either ceftizoxime (2–4 g every 8 h), cefotaxime (1–2 g every 4 h), or latamoxef (2–4 g every 8 h). Of the 84 patients evaluable for efficacy, clinical cure was achieved in 91%, 85%, and 89% of ceftizoxime- (20/22), cefotaxime- (23/27), and latamoxef-treated (31/35) patients, respectively. Adverse reactions occurred in one of 45 ceftizoxime-treated patients, one of 43 cefotaxime-treated patients, and seven of 47 latamoxef-treated patients. Abnormal laboratory values during therapy were seen in 50% of latamoxef-treated and 43% of cefotaxime-treated patients and in 29% of ceftizoxime-treated patients. Hypoprothrombinaemia occurred in five latamoxef-treated patients and one of these patients experienced an episode of haematemesis. In this study, ceftizoxime, cefotaxime, and latamoxef were similarly effective; however, the incidence of side effects was most frequent with latamoxef.
- Subjects
BACTERIAL disease complications; BACTERIAL diseases; CEFOTAXIME; CLINICAL trials; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; PNEUMONIA; RESEARCH; STATISTICAL sampling; EVALUATION research; RANDOMIZED controlled trials; RELATIVE medical risk; BLIND experiment; CEFTAZIDIME; DISEASE complications; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 19, Issue 2, p239
- ISSN
0305-7453
- Publication type
journal article