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- Title
The activity of imipenem on Legionella pneumophila, with a note on the treatment of two cases.
- Authors
Farrell, I. D.; Barker, J.; Chiodini, P. L.; Hutchison, J. G. P.; Geddes, A. M.; Hutchison, J G
- Abstract
An in-vitro assessment of the activity of imipenem, a new carbapenem beta-lactam antibiotic, was undertaken on isolates of Legionella pneumophila. The minimum inhibitory concentrations of imipenem were in the range 0.03 to 0.25 mg/l and turbidimetric studies showed that imipenem had a marked bactericidal effect which was more pronounced than that seen with either rifampicin or erythromycin. Two patients with legionella pneumonia were successfully treated with imipenem as part of a clinical trial of the drug.
- Subjects
COMPARATIVE studies; DOSE-effect relationship in pharmacology; ERYTHROMYCIN; LEGIONELLA; LEGIONNAIRES' disease; RESEARCH methodology; MEDICAL cooperation; MICROBIAL sensitivity tests; RESEARCH; RIFAMPIN; EVALUATION research; CARBAPENEMS; IMIPENEM; PHARMACODYNAMICS; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1985, Vol 16, Issue 1, p61
- ISSN
0305-7453
- Publication type
journal article