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- Title
Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta-analysis.
- Authors
Barros, Ana Waleska Pessoa; Sales, Pedro Henrique da Hora; Silva, Paulo Goberlânio de Barros; Gomes, Ana Claudia Amorim; Carvalho, Alessandra Albuquerque Tavares; Leão, Jair Carneiro
- Abstract
The objective of this systematic review is to evaluate the effectiveness of low-level laser therapy in the treatment of herpes labialis. The searches were carried out independently by 2 researchers and the articles were selected through the electronic databases according to the inclusion and exclusion criteria previously established. Initially, 480 articles were found, of which 7 randomized clinical trials and 1 clinical trial were selected. In total, 928 patients were included. In the meta-analysis, the mean healing time for laser use was significant, showing a mean reduction of 1.37 [CI 95% = 0.92 to 1.82] days for tissue healing (p < 0.0001). In the meta-analysis to evaluate the time for crust formation, there was no significant difference between the groups and no significant reduction in the mean time for crust formation (p = 0.150). Only one of the selected studies had a low risk of bias. The use of low-level laser proved to be effective in the treatment of herpes labialis. However, due to the high risk of bias in the included studies, there is a need to carry out new standardized studies to prove the effectiveness of this therapy.
- Subjects
WOUND healing; META-analysis; PHOTOCHEMOTHERAPY; SYSTEMATIC reviews; HERPES simplex
- Publication
Lasers in Medical Science, 2022, Vol 37, Issue 9, p3393
- ISSN
0268-8921
- Publication type
journal article
- DOI
10.1007/s10103-022-03653-6