We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinicopathological predictors of postoperative long-term myasthenic status in resected thymoma with myasthenia gravis.
- Authors
Suzuki, Takahiro; Hishida, Tomoyuki; Suzuki, Shigeaki; Okubo, Yu; Masai, Kyohei; Kaseda, Kaoru; Asakura, Keisuke; Emoto, Katsura; Asamura, Hisao
- Abstract
Purpose: Surgical patients with thymoma and myasthenia gravis (MG) must have their MG status and oncological outcomes critically monitored. We aimed to identify clinicopathological predictors of the postoperative MG status. Methods: We conducted a retrospective review of 40 consecutive surgical patients with MG-related thymomas between 2002 and 2020. The quantitative myasthenia gravis score (QMGS) and Myasthenia Gravis Foundation of America post-intervention status (MGFA-PIS) were used to evaluate postoperative MG status. Results: All patients underwent extended total thymectomy. The most common WHO type was type B2 (32%), while 65% of patients had type B1–B3 and 35% had type A–AB thymomas. Eleven patients (28%) achieved controlled MG status in MGFA-PIS 6 months after surgery. This controlled status was observed more frequently in type A–AB than in B1–B3 (57% vs. 12%, p = 0.007). In a multivariate analysis, WHO type (A–AB or B1–B3) was an independent predictor of worsening episodes of MG based on the QMGS (Type B1–B3, hazard ratio: 3.23, 95% confidence interval: 1.12–9.25). At the last follow-up, 23 patients (58%) achieved controlled MG status. The 5-year overall survival rate of all patients was 93.7%. Conclusion: The WHO type of thymoma is an informative predictor of postoperative MG status in patients with MG-related thymoma.
- Subjects
AMERICA; MYASTHENIA gravis; THYMECTOMY; WHO (Performer); THYMOMA; CLINICAL pathology; OVERALL survival; MULTIVARIATE analysis
- Publication
Surgery Today, 2024, Vol 54, Issue 7, p787
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-024-02806-0