We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Photochemische Synthesen potentiell hypoglykämisch wirkender 3-Oxazoline.
- Authors
Pfoertner, Karl-Heinz; Bernauer, Karl; Kaufmann, Franz; Lorch, Eckehard
- Abstract
Photochemical Syntheses of 3-Oxazolines which Possibly Exhibit Hypoglycemic Activity Reactions of photochemically generated benzonitrile methylides 2 with carbonyl compounds 3 yielded 3-oxazolines of the types 5 and 6 (Scheme 1). Photooxidation of 5-[ p-(dimethylamino)phenyl]-2,2-dimethyl-4-phenyl-3-oxazoline ( 5a) gave 4′-(2,2-dimethyl-4-phenyl-3-oxazolin-5-yl)- N-methylformanilide ( 6r) which could be transformed to 2,2-dimethyl-5-[ p-(methylamino)phenyl]-4-phenyl-3-oxazoline ( 6s) by photodecarbonylation. Thirty 3-oxazolines of types 5 and 6 have been synthesized and tested by oral and/or intraperitoneal administration to starved rats and obese-hyperglycemic mice.
- Publication
Helvetica Chimica Acta, 1985, Vol 68, Issue 3, p584
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19850680308