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- Title
Neurologische Komplikationen der neuroonkologischen Therapie.
- Authors
Herrlinger, U.; Steinbach, J.P.
- Abstract
Neurological complications of therapeutic procedures for brain tumors are increasingly being recognized. These encompass the classic types of central and peripheral neurotoxicity, such as radiotherapy-induced leukoencephalopathy and platinum-induced neuropathy. However, the advent of novel protocols and targeted therapeutics has expanded the spectrum of neurological complications. A problem of considerable importance is pseudoprogression after radiochemotherapy with temozolomide. Among the new targeted drugs complications of therapy with bevacizumab are the subject of intense discussion. In this review article the neurotoxic potential of intrathecal chemotherapy, kinase inhibitors, immunological strategies and local therapies are summarized. Knowledge about neurological complications of brain tumor therapy procedures is important for risk assessment and patient information.
- Subjects
BRAIN tumor treatment; RADIOTHERAPY; NEUROTOXICOLOGY; PROGRESSIVE multifocal leukoencephalopathy; BEVACIZUMAB; CENTRAL nervous system; MAGNETIC resonance imaging
- Publication
Der Nervenarzt, 2010, Vol 81, Issue 8, p940
- ISSN
0028-2804
- Publication type
Article
- DOI
10.1007/s00115-010-2958-z