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- Title
Solid lipid particles in lipid films to control the diffusive release of 2-heptanone.
- Authors
Bilbao‐Sáinz, Cristina; Chiou, Bor‐Sen; Glenn, Greg M; Gregorsky, Kay S; Williams, Tina G; Wood, Delilah F; Klamczynski, Artur P; Orts, William J
- Abstract
Background Controlled-release formulations of bioactive agents are of increasing interest for effective pest control. Volatile 2-heptanone is a bioactive agent that has shown potential as a pesticide. The aim of this study was to investigate the kinetics of release of 2-heptanone incorporated into lipid films or composite solid lipid particle ( SLP) films. Results Effective 2-heptanone diffusivity was estimated to be between 0.1 and 2.5 mm2 day−1 during the first week and between 0.05 and 0.1 mm2 day−1 during the next 5 weeks. The films that showed better retention of 2-heptanone were the paraffin lipid films. Inclusion of SLPs into paraffin films increased the release rate of 2-heptanone, mainly owing to a decrease in the film firmness as the composite SLP film became less crystalline and more brittle. In contrast, SLPs decreased the kinetics of 2-heptanone release in Acetem films owing to an increase in the film firmness. Conclusions The results indicated that the use of SLPs as a method for controlled release can improve the delivery of the natural pesticide 2-heptanone if the SLPs have good compatibility with the matrix, leading to an increase in firmness of the films without increasing their porosity. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
- Subjects
HEPTANONES; PEST control; PESTICIDE research; SODIUM dodecyl sulfate; DIFFERENTIAL scanning calorimetry; THERMOGRAVIMETRY
- Publication
Pest Management Science, 2013, Vol 69, Issue 8, p975
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.3462