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- Title
Detection of circulating albumin-mRNA by RT-PCR does not indicate metastasizing hepatocellular carcinoma.
- Authors
Leonhardt, U.; Ritzel, U.; Ottleben, M.; Vignoli, A.; Ramadori, G.
- Abstract
Hepatocellular carcinomas (HCC) frequently recur after partial liver resection or orthotopic liver transplantation, possibly because of the presence of a small number of hepatoma cells in the peripheral blood. Detection of circulating HCC cells might improve therapeutic options and could predict disease recurrence resulting from a metastasizing disease. In the present study, human albumin-mRNA was detected by RT-PCR in the peripheral blood of patients with hepatocellular carcinoma. Circulating albumin-specific PRC products were detected in each patient with HCC, but also in healthy volunteers. It is concluded that albumin-mRNA is not specific to circulating hepatoma cells and therefore does not indicate metastasizing disease.
- Publication
Langenbeck's Archives of Surgery, 1997, Vol 382, Issue 2, p83
- ISSN
1435-2443
- Publication type
Article
- DOI
10.1007/BF02465094