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- Title
高效液相色谱■电感耦合等离子体质谱(ICP-MS)法 测定中药材中无机汞、甲基汞、乙基汞
- Authors
孟珊; 刘晓明; 平惠娟; 段琼; 封淑华; 刘永利
- Abstract
In order to accurately determine the content of different forms of mercury in Chinese herbal medicines, the sample was extracted by artificial gas trie juice in the water bath heating. Methanolammonium acetate as the mobile phase, using C18 reversed-phase chromatographic column separation of sample solution, finally the content of three different forms of mercury compounds were determined by ICP-MS-HPLC--ICP--MS was used to establish the method of simultaneous determination of inorganic mercury, methyl mercury, ethyl mercury in Chinese herbal medicine. The results of three different forms of mercury compounds in 0-5--5 ng/mL range are good linear relationship, and the correlation coefficient were greater than 999・ To evaluate the accuracy by the method of standard addition recovery, the recovery is 75. 5%--118%, relative standard deviation(RSD) was 2. 4%--9. 7%. In 106 batches of Chinese herbal medicine, methyl mercury and ethyl mercury have not been detected. The detectable rate of inorganic mercury in samples was 88.7%, and the percent of pass is 100%. The method can accurately and efficiently determinate of the content of three different forms of mercury compounds in Chinese herbal medicine. The main mercury compound of 106 batches in Chinese herbal medicine is inorganic mercury as the existence form. To accumulate basic data and provide technical support for Chinese medicine Yinpian quality safety regulation, the content of 106 batches of 3 different forms of mercury compounds in Chinese herbal medicine were determined.
- Subjects
HERBAL medicine; CHINESE medicine; MERCURY compounds; METHYLMERCURY; HYDRONICS; MERCURY
- Publication
Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue, 2023, Vol 13, Issue 5, p414
- ISSN
2095-1035
- Publication type
Article
- DOI
10.3969/j.issn.2095-1035.2023.05.002