We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recognition of herpesviruses by the innate immune system.
- Authors
Paludan, Søren R.; Bowie, Andrew G.; Horan, Kristy A.; Fitzgerald, Katherine A.; Paludan, Søren R
- Abstract
Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses that replicate in the nucleus, are initially recognized during cellular infection. Surprisingly, this involves multiple PRRs both on the cell surface and within endosomes and the cytosol. In this article we describe recent advances in our understanding of innate detection of herpesviruses, how this innate detection translates into anti-herpesvirus host defence, and how the viruses seek to evade this innate detection to establish persistent infections.
- Subjects
HERPESVIRUSES; NATURAL immunity; PATTERN perception; CELL membranes; DNA viruses; ENDOSOMES; CYTOSOL
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 2, p143
- ISSN
1474-1733
- Publication type
research
- DOI
10.1038/nri2937