We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparative Analysis of Bone Regeneration According to Particle Type and Barrier Membrane for Octacalcium Phosphate Grafted into Rabbit Calvarial Defects.
- Authors
Pyo, Se-Wook; Paik, Jeong-Won; Lee, Da-Na; Seo, Young-Wook; Park, Jin-Young; Kim, Sunjai; Choi, Seong-Ho
- Abstract
This animal study was aimed to evaluate the efficacy of new bone formation and volume maintenance according to the particle type and the collagen membrane function for grafted octacalcium phosphate (OCP) in rabbit calvarial defects. The synthetic bone substitutes were prepared in powder form with 90% OCP and granular form with 76% OCP, respectively. The calvarial defects were divided into four groups according to the particle type and the membrane application. All specimens were acquired 2 weeks (n = 5) and 8 weeks (n = 5) after surgery. According to the micro-CT results, the new bone volume increased at 2 weeks in the 76% OCP groups compared to the 90% OCP groups, and the bone volume ratio was significantly lower in the 90% OCP group after 2 weeks. The histomorphometric analysis results indicated that the new bone area and its ratio in all experimental groups were increased at 8 weeks except for the group with 90% OCP without a membrane. Furthermore, the residual bone graft area and its ratio in the 90% OCP groups were decreased at 8 weeks. In conclusion, all types of OCP could be applied as biocompatible bone graft materials regardless of its density and membrane application. Neither the OCP concentration nor the membrane application had a significant effect on new bone formation in the defect area, but the higher the OCP concentration, the less graft volume maintenance was needed.
- Subjects
BONE regeneration; BONE substitutes; BONE growth; X-ray computed microtomography; BONE grafting; PHOSPHATES
- Publication
Bioengineering (Basel), 2024, Vol 11, Issue 3, p215
- ISSN
2306-5354
- Publication type
Article
- DOI
10.3390/bioengineering11030215