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- Title
Information-Rich Multi-Functional OCT for Adult Zebrafish Intra- and Extracranial Imaging.
- Authors
Yang, Di; Wang, Weike; Yuan, Zhuoqun; Liang, Yanmei
- Abstract
The zebrafish serves as a valuable animal model for both intra- and extracranial research, particularly in relation to the brain and skull. To effectively investigate the development and regeneration of adult zebrafish, a versatile in vivo imaging technique capable of showing both intra- and extracranial conditions is essential. In this paper, we utilized a high-resolution multi-functional optical coherence tomography (OCT) to obtain rich intra- and extracranial imaging outcomes of adult zebrafish, encompassing pigmentation distribution, tissue-specific information, cranial vascular imaging, and the monitoring of traumatic brain injury (TBI). Notably, it is the first that the channels through the zebrafish cranial suture, which may have a crucial function in maintaining the patency of the cranial sutures, have been observed. Rich imaging results demonstrated that a high-resolution multi-functional OCT system can provide a wealth of novel and interpretable biological information for intra- and extracranial studies of adult zebrafish.
- Subjects
BRACHYDANIO; OPTICAL coherence tomography; CRANIAL sutures; BRAIN injuries; ADULTS
- Publication
Bioengineering (Basel), 2023, Vol 10, Issue 7, p856
- ISSN
2306-5354
- Publication type
Article
- DOI
10.3390/bioengineering10070856