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- Title
青霉属真菌 Penicillium sp. CPCC 400786 的抗病毒活性成分.
- Authors
ZHANG De-Wu; ZHAO Jian-Yuan; ZHOU Jia-Qi; WEI Tao; YU Li-Yan
- Abstract
The activity of ethyl acetate extract of the fungus Penicillium sp. CPCC 400786 was evaluated by using anti-HIV inhibitor screening model. The result showed that ethyl acetate extract presented a significant inhibiting effect on HIV. Eight compounds were separated and purified by silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC, and their structures were identified as oxalicine A (1), oxalicine B (2), cis-4,6-dihydroxymellein (3), linoleic acid (4), cis-9-octadecenoic acid (5), tetradecanoic acid (6), uracil (7), thymine (8) by analysis of spectroscopic data. Compounds 1 and 2 were meroterpene derivatives. Compounds 1–6 were evaluated for anti-HIV and anti-H1N1 activities. Compound 1 displayed significant anti-H1N1 activity with the IC50 value of 38.5μmol/L, and the activity was slightly weaker than that of positive control (ribavirin, IC50=20.5μmol/L). Compounds 1 and 2 showed anti-HIV activities with the IC50 values of 22.4 and 67.8μmol/L, respectively. Compounds 3–6 were inactive. More antiviral meroterpenoids from the genus Penicillium need further investigation.
- Publication
Mycosystema, 2020, Vol 39, Issue 2, p434
- ISSN
1672-6472
- Publication type
Article
- DOI
10.13346/j.mycosystema.190327