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- Title
中药单体调控“细胞自噬”防治皮瓣坏死.
- Authors
马岁录; 何志军; 刘 涛; 李 岩; 何元旭; 何 波; 王威威; 魏晓涛
- Abstract
BACKGROUND: In recent years, it has been found that some traditional Chinese medicine monomers can alleviate oxidative stress and apoptosis of the skin flap, promote vascular regeneration of the skin flap and prevent skin flap necrosis by activating autophagy. OBJECTIVE: To review the research progress of traditional Chinese medicine monomer regulating autophagy in preventing flap necrosis. METHODS: The Chinese and English key words were “traditional Chinese medicine (TCM), autophagy, skin flaps”. The first author searched the relevant articles published in CNKI and PubMed databases from January 2010 to October 2022. A total of 196 articles were retrieved in the preliminary screening and then screened according to the inclusion and exclusion criteria. The quality assessment was conducted by reading the literature titles and abstracts. Finally, 55 articles were summarized. RESULTS AND CONCLUSION: (1) The regulation of autophagy is mediated by AMPK/mTOR, PI3K/AKT and other signaling pathways. Activation of autophagy can alleviate the oxidative stress and apoptosis of the flap, promote the regeneration of blood vessels in the flap, and prevent flap necrosis. (2) Terpenoids (Betulinic acid, Andrographolide, Notoginseng Triterpenes, Catalpa), phenolic compounds (Resveratrol, Curcumin, Gastrodin), phenolic acids (Salvianolic acid B) and steroid compounds (Pseudoginsenoside F11) in traditional Chinese medicine monomers can alleviate oxidative stress and apoptosis of skin flap by regulating related signaling pathways to activate autophagy, promote skin flap angiogenesis and promote skin flap survival. (3) Studying the research progress of traditional Chinese medicine monomer to prevent flap necrosis by regulating autophagy can provide a reference and theoretical basis for traditional Chinese medicine to prevent flap necrosis and promote flap healing in the clinic.
- Subjects
RESVERATROL; CHINESE medicine; BETULINIC acid; PI3K/AKT pathway; AMP-activated protein kinases; OXIDATIVE stress
- Publication
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu, 2024, Vol 28, Issue 1, p153
- ISSN
2095-4344
- Publication type
Article
- DOI
10.12307/2023.755