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- Title
H19 基因在肿瘤研究领域的研究进展.
- Authors
王晓东; 王晓娟; 赵鹏飞; 陈文捷; 吴慧哲; 魏敏杰
- Abstract
Since human imprinted genes in 11P15.5 was found, it had been proved that various human physiological abnormality associated with it. As one of the first identified imprinted non-coding RNA genes, more attention is paid to lncRNA H19 by many scholars not only because it's linked with Beckwith-Wiedemann syndrome (BWS) and Russell syndrome (SRS), but also H19 gene is the only imprinted gene belonging to long non-coding RNA related with a variety of tumors which can also produce microRNA675 and lncRNA 91H coming from H19 gene antisense-coding. This paper will review possible mechanisms of H19 gene in tumorigenesis process and its research status in Cancer therapy from four aspects: imprinting feature, single nucleotide polymorphisms, lncRNA character and its possible action signal axis in cancer.
- Publication
Fudan University Journal of Medical Sciences, 2017, Vol 44, Issue 2, p224
- ISSN
1672-8467
- Publication type
Article
- DOI
10.3969/j.issn.1672-8467.2017.02.017