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- Title
Tumorigenesis: Micromanager.
- Authors
Dell, Helen
- Abstract
The article focuses on a study related to MicroRNAs (miRNAs) that are now recognized to be key regulators of development and cell differentiation. Unsurprisingly, therefore, evidence is emerging that mi-RNAs can be mutated or abnormally expressed in human cancers. Steven M. Johnson et al. now provide a link between certain miRNAs and the notorious RAS oncogenic signalling pathway, suggesting a mechanism by which these miRNAs might regulate tumorigenesis. Animal miRNAs are proposed to exert their regulatory effects by binding to complementary sequences in the 3? untranslated regions of their target mRNA, thereby controlling translation.
- Subjects
RNA; CELL differentiation; GENETIC mutation; CANCER; CARCINOGENESIS; ONCOGENES
- Publication
Nature Reviews Cancer, 2005, Vol 5, Issue 5, p337
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc1614