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- Title
Side alternating vibration training in patients with mitochondrial disease: a pilot study.
- Authors
Newell, Christopher; Ramage, Barbara; Robu, Ion; Shearer, Jane; Khan, Aneal
- Abstract
Background: Side alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise. We hypothesized that patients with mitochondrial myopathies, who experience muscle weakness, may see an improvement in muscle power with SAVT. Methods: Patients with mitochondrial disease started either a treatment (SAVT) or control phase (standing without vibration) for 12 weeks, then 12 weeks of washout, and then a 12-week cross-over. The main outcome measure was peak jump power (PJP). We compared this to a natural history cohort from clinic. Results: Seven out of 13 patients completed at least 80% of their SAVT sessions and were analyzed. The ΔPJP after the control phase was -2.7 ± 1.7 W/kg (mean ± SEM), SAVT was +2.8 ± 0.6 W/kg (p < 0.05) and from the natural history cohort was -2.4 ± 0.8 W/kg/year. Conclusions: SAVT is well tolerated and may improve muscle power in mitochondrial disease patients.
- Subjects
MITOCHONDRIAL pathology; PHYSICAL therapy; VIBRATION therapy
- Publication
Archives of Physiotherapy, 2017, Vol 7, p1
- ISSN
2057-0082
- Publication type
Article
- DOI
10.1186/s40945-017-0038-4