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- Title
低频脉冲电磁场对大鼠应激性溃疡胃壁血液循环及超微结构的影响.
- Authors
焦明克; 王芳利; 胡劼; 焦琳; 张鹏
- Abstract
Objective To determine non-thermal biological effect of low frequency pulsed electromagnetic field (LFPEF)on the stomach blood circulation and ultra microstructure of rat stress ulcer. Methods Thirty-six Sprague-Dawley rats were assigned to three equal groups: control, ulcer without interference group (UW) and ulcer exposure groups (UE). The rats stress ulcer models were constructed with the combination method of soak and bind in the low-pressure and hypoxia circumstance. Based on the singlechip, a LFPEF generator with adjustable frequency, amplitude and duty ratio was developed. Then the stomachs ofthe rats were exposed to the LFPEF generator 3 hours per day. On days 1, 3, 5 and 7, the blood circulation of the stomach was analyzed by the content of the serum NO and contrast ultrasonography. In addition, the ulcer tissue was taken out for section -staining. Finally, the pathological change of the stomach ultra microstructure was observed under a light microscope. Results On different days, the contents of the serum NO and microbubble concentration of UE group were significantly higher than those of the UW group (P<0.05). The pathological observation showed that the restoration of the gastric tissue in UE group was faster than that in the UW group (P<0.05). Conclusion LFPEF with certain proper parameter could improve the gastric tissue blood circulation and accelerate the stress ulcer restoration.
- Subjects
ELECTROMAGNETIC fields &; health; BLOOD circulation; MICROSTRUCTURE; ENDOSCOPIC ultrasonography; LABORATORY mice
- Publication
Chinese Medical Equipment Journal, 2018, Vol 39, Issue 5, p35
- ISSN
1003-8868
- Publication type
Article
- DOI
10.7687/j.issn1003-8868.2018.05.035