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- Title
美常安联合柳氮磺吡啶治疗溃疡性结肠炎的疗效及对血清TNF-α、IL-6、IL-8水平的影响
- Authors
李杨麟; 喻晓东; 苏林; 唐运东; 秦漓漓; 王芬利
- Abstract
Objective: To explore the efficacy of Meichangan combined with sulfasalazine in treatment of ulcerative colitis(UC)and its influence on the serum TNF-α, IL-6, IL-8. Methods: A total of 100 patients with UC, who were treated in Guilin Second People's Hospital from September 2012 to December 2014, were randomly divided into control group(n=50) and observation group(n=50). The control group was treated with sulfasalazine, while the observation group was treated with Meichangan combined with sulfasalazine. The clinical efficacy, clinical symptoms improvement, incidence of adverse reactions, and the changes of serum TNF-α, IL-6, IL-8 level before and after treatment in the two groups were statistically analyzed. Results: The total effective rate(92.00%) in the observation group was significantly higher than that(48.00%) in the control group(P<0.05); The main clinical symptoms of two groups after treatment were significantly improved than before treatment(P<0.05), meanwhile the main symptom remission rate after treatment in observation group was obviously higher than that in control group(P<0.05). The serum TNF-α, IL-6, IL-8 levels in the two groups after treatment were significantly lower than before treatment, the above indexes in observation group were significantly lower than those in control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P<0.05). Conclusion:Meichangan plus sulfasalazine has a good clinical effect in the treatment of patients with UC, and it can significantly improve the clinical symptoms and reduce the serum TNF-α, IL-6, IL-8 levels, which is worth of clinical application.
- Publication
Progress in Modern Biomedicine, 2016, Vol 16, Issue 10, p1926
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2016.10.032