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- Title
Influence of Oxidation Conditions on the Yield of 2-Substituted Imidazole-4,5-dicarboxylic Acids.
- Authors
Brusina, M. A.; Gubina, Yu. A.; Nikolaev, D. N.; Ramsh, S. M.; Piotrovskii, L. B.
- Abstract
Conditions were found which allow 2-alkyl-substituted imidazole-4,5-dicarboxylic acids to be synthesized in preparative quantities by the oxidation of 2-alkylbenzimidazoles with hydrogen peroxide. It was shown that optimal results can be obtained at the concentration of 2-alkylimidazole in sulfuric acid of 1 M and the hydrogen peroxide: 2-alkylbenzimidazole molar ratio of 11: 1. Oxidation under these conditions results in higher yields of the target 2-alkylimidazole-4,5-dicarboxylic acids, including those with a branched alkyl group.
- Subjects
HYDROGEN peroxide; OXIDATION; DICARBOXYLIC acids; HYDROGEN; PEROXIDES
- Publication
Russian Journal of General Chemistry, 2018, Vol 88, Issue 5, p874
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363218050055