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- Title
Guanidines based on tryptamine and histamine in reactions with electrophiles.
- Authors
Shestakov, A. S.; Sidorenko, O. E.; Shikhaliev, Kh. S.; Pavlenko, A. A.
- Abstract
Reactions of 4,6-dimethylpyrimidin-2-ylcyanamide with tryptamines and histamine gave the corresponding disubstituted guanidines. The molecular parameters of the products were calculated using GAUSSIAN 03 software package. The direction of electrophilic attack on these compounds was predicted on the basis of the geometric shape of their highest occupied molecular orbital (HOMO) and molecular electrostatic potential (MEP) maps. Acyl, carbamoyl, and cyclic derivatives were obtained, whose structure was consistent with the results of quantum-chemical calculations.
- Subjects
GUANIDINES; TRYPTAMINE; HISTAMINE; ELECTROPHILES; MOLECULAR dynamics; ELECTROSTATICS
- Publication
Russian Journal of General Chemistry, 2007, Vol 77, Issue 10, p1749
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363207100143