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- Title
Monocationic Chlorin Photosensitizer for Efficient Photoinactivation of Antibiotic-Resistant Gram-Negative Microorganisms.
- Authors
Kustov, A. V.; Kukushkina, N. V.; Lyalyakina, E. V.; Solomonova, N. N.; Gagua, A. K.; Koifman, O. I.; Berezin, D. B.
- Abstract
A water-soluble monocationic chlorin photosensitizer for antimicrobial photodynamic therapy of superficial localized infections has been proposed. The antimicrobial activity of this compound against planktonic forms of nosocomial antibiotic-resistant gram-negative pathogens, Pseudomonas aeruginosa, Enterobacter cloacae, and Acinetobacter baumannii, has been studied in comparison with the activity of the photosensitizer Fotoran e6, widely used in the clinical photodynamic therapy of tumors. It has been shown that both photosensitizers possess low dark toxicity; however, the light toxicity of the monocationic chlorin is higher by several orders of magnitude, and it can be proposed as a new agent for the antimicrobial photodynamic therapy.
- Subjects
GRAM-negative bacteria; PHOTODYNAMIC therapy; PHOTOSENSITIZERS; ENTEROBACTER cloacae; ACINETOBACTER baumannii; PSEUDOMONAS aeruginosa
- Publication
Doklady Chemistry, 2023, Vol 508, Issue 1, p32
- ISSN
0012-5008
- Publication type
Article
- DOI
10.1134/S0012500823700155