We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes.
- Authors
Chen, Liang-Yun; Kao, Ting-Wan; Chen, Chang-Cyuan; Niaz, Noreen; Lee, Hsin-Lun; Chen, Yu-Hsin; Kuo, Chia-Chun; Shen, Yao-An
- Abstract
Exosomes are effective therapeutic vehicles that may transport their substances across cells. They are shown to possess the capacity to affect cell proliferation, migration, anti-apoptosis, anti-scarring, and angiogenesis, via the action of transporting molecular components. Possessing immense potential in regenerative medicine, exosomes, especially stem cell-derived exosomes, have the advantages of low immunogenicity, minimal invasiveness, and broad clinical applicability. Exosome biodistribution and pharmacokinetics may be altered, in response to recent advancements in technology, for the purpose of treating particular illnesses. Yet, prior to clinical application, it is crucial to ascertain the ideal dose and any potential negative consequences of an exosome. This review focuses on the therapeutic potential of stem cell-derived exosomes and further illustrates the molecular mechanisms that underpin their potential in musculoskeletal regeneration, wound healing, female infertility, cardiac recovery, immunomodulation, neurological disease, and metabolic regulation. In addition, we provide a summary of the currently effective techniques for isolating exosomes, and describe the innovations in biomaterials that improve the efficacy of exosome-based treatments. Overall, this paper provides an updated overview of the biological factors found in stem cell-derived exosomes, as well as potential targets for future cell-free therapeutic applications.
- Subjects
WOUND healing; EXOSOMES; FEMALE infertility; METABOLIC regulation; REGENERATIVE medicine; SKIN regeneration; CELL proliferation
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 7, p1018
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12071018