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- Title
Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers.
- Authors
Ojalvo-Sanz, Ana Cristina; López-Mascaraque, Laura
- Abstract
During embryonic development, progenitor cells are progressively restricted in their potential to generate different neural cells. A specific progenitor cell type, the radial glial cells, divides symmetrically and then asymmetrically to produce neurons, astrocytes, oligodendrocytes, and NG2-glia in the cerebral cortex. However, the potential of individual progenitors to form glial lineages remains poorly understood. To further investigate the cell progeny of single pallial GFAP-expressing progenitors, we used the in vivo genetic lineage-tracing method, the UbC-(GFAP-PB)-StarTrack. After targeting those progenitors in embryonic mice brains, we tracked their adult glial progeny in lower cortical layers. Clonal analyses revealed the presence of clones containing sibling cells of either a glial cell type (uniform clones) or two different glial cell types (mixed clones). Further, the clonal size and rostro-caudal cell dispersion of sibling cells differed depending on the cell type. We concluded that pallial E14 neural progenitors are a heterogeneous cell population with respect to which glial cell type they produce, as well as the clonal size of their cell progeny.
- Subjects
PROGENITOR cells; EMBRYOLOGY; CELL size; CELL populations; NEUROGLIA; CLONE cells; MOLECULAR cloning
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 11, p3237
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10113237