We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Topical formulation containing chitosan-chamomile microparticles in cutaneous wound healing in rats.
- Authors
Garbuio, Danielle Cristina; Leite, Marcel Nani; Figueiredo, Sonia Aparecida; de Freitas, Luís Alexandre Pedro; de Carvalho, Emília Campos; Frade, Marco Andrey Cipriani
- Abstract
Objective: The aim of this research was to evaluate the efficacy of a topical formulation containing chitosan-chamomile microparticles in cutaneous healing in rats. Method: Male Wistar rats (n=57) were randomly distributed into three groups: treatment; vehicle; and control. Evaluations were performed on days 2, 7 and 14 after the surgical procedure using skin lesion photography, and histological and biochemical analyses. Results: The results showed that there was no difference in the healing index and in the histological analysis of the inflammatory infiltrate among groups. Fibrogenesis was more significant in the group treated with the test formulation at day 7, and angiogenesis was greater in the vehicle and chamomile groups at day 2. The quantification of hydroxyproline showed a higher amount of collagen in the group treated with chamomile, mainly at day 14, although the histological quantification of collagen showed no difference between the groups. Conclusion: From the results of this study, it can be concluded that the formulation, although it had no effect on the healing time, improved the quality of the cicatricial tissue formed with a greater quantity of fibroblasts and collagen.
- Subjects
POLYSACCHARIDES; WOUND healing; BIOLOGICAL models; COLLAGEN; KRUSKAL-Wallis Test; ROMAN chamomile; PHARMACEUTICAL technology; ANIMAL experimentation; BLOOD chemical analysis; OPERATIVE surgery; ONE-way analysis of variance; TIME; GERMAN chamomile; RATS; COMPARATIVE studies; HISTOLOGICAL techniques; PHOTOGRAPHY; DESCRIPTIVE statistics; PROLINE; PHARMACEUTICAL chemistry; STATISTICAL sampling; DATA analysis software
- Publication
Journal of Wound Care, 2023, Vol 32, Issue Sup3a, pxxii
- ISSN
0969-0700
- Publication type
Article
- DOI
10.12968/jowc.2023.32.Sup3a.xxii