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- Title
Notch and the Awesome Power of Genetics.
- Authors
Greenwald, Iva
- Abstract
Notch is a receptor that mediates cell-cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the elucidation of the unusual mechanism of signal transduction a little over a decade ago. As an essay for the GENETICS Perspectives series, it is my personal and critical commentary as well as an historical account of discovery.
- Subjects
NOTCH genes; CELL communication; CELLULAR signal transduction; DROSOPHILA genetics; GENETIC research
- Publication
Genetics, 2012, Vol 191, Issue 3, p655
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.112.141812