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- Title
Clinical significance of preoperative C-reactive protein and squamous cell carcinoma antigen levels in patients with penile squamous cell carcinoma.
- Authors
Li, Zai‐Shang; Yao, Kai; Li, Yong‐Hong; Chen, Jie‐Ping; Deng, Chuang‐Zhong; Zhao, Qi; Chen, Peng; Wang, Bin; Mi, Qi‐Wu; Liu, Zhuo‐Wei; Qin, Zi‐Ke; Han, Hui; Zhou, Fang‐Jian
- Abstract
Objective To evaluate the relevance of C-reactive protein ( CRP) and squamous cell carcinoma antigen ( SCC-Ag) levels in relation to clinicopathological factors and prognosis in penile cancer. Patients and Methods A total of 124 Chinese patients with penile squamous cell carcinoma ( SCC), treated between November 2007 and October 2014, were analysed retrospectively. Receiver-operating characteristic curves were used to identify the combination of markers with the best sensitivity and specificity for prognosis prediction. Statistical data analysis was performed using a non-parametric method, and survival analysis was performed using the log-rank test and Cox proportional hazard model. Results Levels of CRP ≥4.5 mg/L and SCC-Ag ≥1.4 ng/ mL were both significantly associated with lymph node metastasis ( LNM) laterality (chi-squared trend test, P = 0.041), extranodal extension (chi-squared trend test, P < 0.001), pelvic LNM (chi-squared trend test, P = 0.024), pathological tumour status (chi-squared trend test, P = 0.002), pathological nodal status (chi-squared trend test, P < 0.001), and disease-specific survival ( DSS; log-rank test, P < 0.001). Moreover, the influence of CRP and SCC-Ag levels on DSS ( P = 0.033, hazard ratio 3.390, 95% confidence interval 1.104-10.411) remained after adjusting for smoking history, phimosis, tumour status, tumour cell differentiation and nodal status. Conclusions The present study shows that the combined measurement of preoperative CRP and SCC-Ag levels may serve as an independent biomarker for LNM, advanced tumour stage and DSS in patients with penile SCC.
- Subjects
CARCINOMA; ADENOCARCINOMA; CARCINOMA in situ; CHORDOMA; EHRLICH ascites carcinoma
- Publication
BJU International, 2016, Vol 118, Issue 2, p272
- ISSN
1464-4096
- Publication type
Article
- DOI
10.1111/bju.13379