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- Title
From an understanding of etiopathogenesis to novel therapies--what is new in the treatment of celiac disease?
- Authors
Skoracka, Kinga; Hryhorowicz, Szymon; Tovoli, Francesco; Raiteri, Alberto; Rychter, Anna Maria; Słomski, Ryszard; Dobrowolska, Agnieszka; Granito, Alessandro; Krela-Kaźmierczak, Iwona
- Abstract
Celiac disease, a chronic autoimmune disorder caused by genetic factors and exposure to gluten, is increasingly being recognized and diagnosed in both children and adults. Scientists have been searching for a cure for this disease for many years, but despite the impressive development of knowledge in this field, a gluten-free diet remains the only recommended therapy for all patients. At the same time, the increasing diagnosis of celiac disease in adults, which was considered a childhood disease in the 20th century, has opened a discussion on the etiopathology of the disease, which is proven to be very complex and involves genetic, immunological, nutritional, environmental and gut microbiotarelated factors. In this review, we extensively discuss these factors and summarize the knowledge of the proposed state-of-the-art treatments for celiac disease to address the question of whether a better understanding of the etiopathogenesis of celiac disease has opened new directions for therapy.
- Subjects
CELIAC disease; THERAPEUTICS; GLUTEN-free diet; GENETIC disorders; JUVENILE diseases; OLDER patients
- Publication
Frontiers in Pharmacology, 2024, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2024.1378172