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- Title
Metabolomics in rheumatoid arthritis: Advances and review.
- Authors
Lingxia Xu; Cen Chang; Ping Jiang; Kai Wei; Runrun Zhang; Yehua Jin; Jianan Zhao; Linshuai Xu; Yiming Shi; Shicheng Guo; Dongyi He
- Abstract
Rheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations. The metabolic profiles of patients with RA can be determined using targeted and non-targeted metabolomics technology. Metabolic changes in glucose, lipid, and amino acid levels are involved in glycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway, the arachidonic acid metabolic pathway, and amino acid metabolism. These alterations in metabolic pathways and metabolites can fulfill bio-energetic requirements, promote cell proliferation, drive inflammatory mediator secretion, mediate leukocyte infiltration, induce joint destruction and muscle atrophy, and regulate cell proliferation, which may reflect the etiologies of RA. Differential metabolites can be used as biomarkers for the diagnosis, prognosis, and risk prediction, improving the specificity and accuracy of diagnostics and prognosis prediction. Additionally, metabolic changes associated with therapeutic responses can improve the understanding of drug mechanism. Metabolic homeostasis and regulation are new therapeutic strategies for RA. In this review, we provide a comprehensive overview of advances in metabolomics for RA.
- Subjects
AMINO acid metabolism; METABOLOMICS; KREBS cycle; PENTOSE phosphate pathway; METABOLIC regulation; EXPERIMENTAL arthritis; RHEUMATOID arthritis
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.961708