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- Title
Mycobacterial signaling through toll-like receptors.
- Authors
Basu, Joyoti; Dong-Min Shin; Eun-Kyeong Jo
- Abstract
Studies over the past decade have helped to decipher molecular networks dependent on Toll-like receptor (TLR) signaling, in mycobacteria-infected macrophages. Stimulation of TLRs by mycobacteria and their antigenic components rapidly induces intracellular signaling cascades involved in the activation of nuclear factor-κB and mitogen-activated protein kinase pathways, which play important roles in orchestrating proinflammatory responses and innate defense through generation of a variety of antimicrobial effector molecules. Recent studies have provided evidence that mycobacterial TLR-signaling cross talks with other intracellular antimicrobial innate pathways, the autophagy process and functional vitamin D receptor (VDR) signaling. In this article we describe recent advances in the recognition, responses, and regulation of mycobacterial signaling through TLRs.
- Subjects
MYCOBACTERIUM; TOLL-like receptors; MYCOBACTERIA; INFLAMMATION; PROTEIN kinases
- Publication
Frontiers in Cellular & Infection Microbiology, 2012, Vol 2, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2012.00145