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- Title
Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up.
- Authors
Muñoz, Gabriela; Vergara, Camilo; Martínez, Gabriela; Apt, Werner; Zulantay, Inés
- Abstract
In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P<0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.
- Subjects
CHAGAS' disease treatment; IMMUNOGLOBULIN G; TRYPANOSOMA cruzi; IMMUNOFLUORESCENCE; MANN Whitney U Test
- Publication
Korean Journal of Parasitology, 2019, Vol 57, Issue 1, p39
- ISSN
0023-4001
- Publication type
Article
- DOI
10.3347/kjp.2019.57.1.39