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- Title
Improvement of left ventricular wall synchronization with multisite ventricular pacing in heart failure: a prospective study using Doppler tissue imaging
- Authors
Lafitte, Stephane; Garrigue, Stephane; Perron, Jean-Marie; Bordachar, Pierre; Reuter, Sylvain; Jaïs, Pierre; Haïssaguerre, Michel; Clementy, Jacques; Roudaut, Raymond; Jaïs, Pierre; Haïssaguerre, Michel
- Abstract
<bold>Unlabelled: </bold>We sought to assess right, left and biventricular pacing effects on myocardial function by using pulsed-Doppler tissue imaging (DTI) and automated border detection (ABD) techniques which provide electromechanical delay (EMD) assessment of the different left ventricular walls. <bold>Methods: </bold>15 patients (67+/-7 years) with drug-resistant primitive dilated cardiomyopathy and QRS> or =140 ms received a pacemaker for multisite ventricular pacing. Echocardiography was performed after 1 month of biventricular pacing (BVP). Echocardiographic measurements were recorded during spontaneous rhythm (SpR), right ventricular pacing (RVP), left ventricular pacing (LVP) and BVP. <bold>Results: </bold>LV ejection fraction was statistically similar between the four rhythms. BVP showed a significant EMD decrease for the lateral LV wall vs. SpR, RVP and even LVP. LVP resulted in significantly longer aortic pre-ejection time vs. BVP while the EMD temporal dispersion (time between the shortest regional EMD and the longest one) was similar in the two modes. <bold>Conclusions: </bold>BVP and LVP substantially reduce the EMD temporal dispersion of the four LV walls, but with a longer aortic pre-ejection time for LVP. In RVP, LVP and BVP, the septal LV wall is always activated later than during SpR. BVP and LVP are associated with a mitral regurgitation reduction.
- Subjects
LEFT heart ventricle; CARDIOMYOPATHIES; ECHOCARDIOGRAPHY; CARDIAC imaging; MITRAL valve insufficiency
- Publication
European Journal of Heart Failure, 2004, Vol 6, Issue 2, p203
- ISSN
1388-9842
- Publication type
journal article
- DOI
10.1016/j.ejheart.2003.10.008