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- Title
Initial metformin or sulphonylurea exposure and cancer occurrence among patients with type 2 diabetes mellitus.
- Authors
Qiu, H.; Rhoads, G. G.; Berlin, J. A.; Marcella, S. W.; Demissie, K.
- Abstract
Aim This was a retrospective cohort study of type 2 diabetes patients, to evaluate the association between initial metformin or sulphonylurea treatment and cancer incidence. Methods Patients identified in the UK Clinical Practice Research Datalink ( CPRD), previously General Practice Research Database, during 1995-2008 who were initially stabilized on OHA monotherapy, including metformin, sulphonylurea, thiazolidinediones ( TZDs) or meglitinides, were included in the cohort. New diagnoses of cancer, including malignant solid tumours and haematological malignancies, occurring during the follow-up were identified from the cohort. Age-standardized incidence rates were estimated and compared between metformin and sulphonylurea exposure groups. Results The age standardized incidences of cancer were 7.5 and 8.5 per 1000 person-years for the metformin and sulphonylurea exposure groups, respectively. After adjusting for potential confounders, the hazard ratios ( HR) for malignant solid tumours and haematological malignancies were 1.06 (95% CI: 0.98, 1.15) and 0.98 (95% CI: 0.67, 1.43) for sulphonylurea group as compared to the metformin group, respectively. For individual cancers, the HRs were 1.17 (95% CI: 0.95, 1.44), 1.04 (95% CI: 0.83, 1.31) and 0.88 (95% CI: 0.71, 1.11) for colorectal cancer, breast cancer and prostate cancer, respectively. Conclusion This study provides evidence that cancer incidence in the first few years after starting metformin or sulphonylurea therapy in type 2 diabetes patients is not much affected by choice of hypoglycaemic drug class.
- Subjects
CLINICAL trials; METFORMIN; HYPOGLYCEMIC agents; TYPE 2 diabetes treatment; CANCER risk factors
- Publication
Diabetes, Obesity & Metabolism, 2013, Vol 15, Issue 4, p349
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.12036