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- Title
Effects of exendin-4 on islets from type 2 diabetes patients.
- Authors
Lupi, R.; Mancarella, R.; Del Guerra, S.; Bugliani, M.; Del Prato, S.; Boggi, U.; Mosca, F.; Filipponi, F.; Marchetti, P.
- Abstract
Exendin-4 is a dipeptidyl peptidase IV (DPP-IV)-resistant glucagon-like peptide1 (GLP-1) mimetic and its synthetic counterpart, exenatide, is being used in the therapy of type 2 diabetes (T2DM). No information, however, is currently available as for the direct action of exendin-4 on human T2DM islets. In the present study, we exposed pancreatic islets prepared from non-diabetic and T2DM subjects to exendin-4 for 48 h and found that the compound had several, direct beneficial actions on insulin secretion and the expression of genes involved in beta-cell function and differentiation.
- Subjects
PEOPLE with diabetes; TYPE 2 diabetes; CARBOHYDRATE intolerance; PANCREATIC secretions; PEPTIDES
- Publication
Diabetes, Obesity & Metabolism, 2008, Vol 10, Issue 6, p515
- ISSN
1462-8902
- Publication type
Letter
- DOI
10.1111/j.1463-1326.2007.00838.x