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- Title
Case Report Acute renal tubular injury with acute hepatitis A infection: Is it just a coincidence?
- Authors
Shroff, Gautam R.; Badve, Sunil V.; Joshi, Anand G.; Desai, Devendra C.; Abraham, Philip; Sirsat, Rasika A.
- Abstract
Acute renal failure has rarely been reported in association with acute hepatitis A infection. The commonest form of renal injury in such patients has been found to be acute tubular necrosis. We report two cases of hepatitis A infection in which acute renal failure occurred very early in the course of the illness and had a clinical presentation and recovery pattern suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to the course of hepatic dysfunction. Patient 1 needed dialysis, whereas patient 2 did not need dialysis and had a very rapid recovery from renal function in spite of having more severe azotaemia. Patient 2 was administered acetylcysteine in high doses for suspected fulminant hepatic failure. A potential benefit of a high dose of acetylcysteine in recovery of renal function from acute tubular necrosis is postulated.
- Subjects
ACUTE kidney failure; HEPATITIS A; LIVER diseases; RENAL tubular transport disorders; NECROSIS; DIALYSIS (Chemistry); KIDNEY diseases
- Publication
Nephrology, 2004, Vol 9, Issue 1, p44
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/j.1440-1797.2003.00224.x